GRO Biosciences raises $25M Series A round to expand the amino acid alphabet and deliver on the promise of protein therapeutics

GRO Biosciences Inc. (“GRObio”), an emerging biotechnology company leveraging groundbreaking science to expand the amino acid alphabet and deliver on the promise of protein therapeutics, today announced the closing of a Series A financing totaling $25 million co-led by Leaps by Bayer and Redmile Group. The financing was joined by lead seed investors Digitalis Ventures, Innovation Endeavors and others bringing the total investment to $31.2 million.

GRO Biosciences raises $25M Series A round to expand the amino acid alphabet and deliver on the promise of protein therapeutics

GRObio’s mission is to transform protein-based therapies for increasingly prevalent chronic medical conditions including autoimmune and metabolic diseases. Protein therapeutics represent a nearly $200 billion market, yet product stability, immunogenicity, and delivery into the cell remain significant obstacles to treatment. GRObio is identifying, addressing, and removing these and other limitations to provide safer, simpler, and more effective therapies that improve the lives of patients. The capital raised will support development of the GRO platform, scale-up of bioprocess manufacturing, preclinical validation studies and IND-enabling studies for GRObio’s pipeline of unique non-standard amino acid (NSAA) protein therapeutics to treat autoimmune and metabolic diseases.

“We are thrilled for the support of our existing and new investors, including Leaps by Bayer and Redmile Group, who share our vision of an expanded amino acid alphabet that overcomes the challenges of current protein therapies to improve health outcomes for countless patients,” said Daniel J. Mandell, PhD, Co-Founder and Chief Executive Officer of GRO Biosciences. “Using our GRO platform and proprietary biofoundry technologies, our team has designed, tested and selected our first families of NSAA chemistries to drive our product pipeline, focused initially on autoimmune and metabolic disorders. Our plan is to simultaneously pursue strategic partnerships to keep core value in the company while advancing our own internally developed programs. I look forward to providing updates on the continued progress of our platform and pipeline.”

“As one of its key challenges, Leaps by Bayer is committed to advancing paradigm-shifting breakthroughs to permanently reverse autoimmune disease,” said Jürgen Eckhardt, MD, MBA, Head of Leaps by Bayer. “Partnering with GRObio is an outstanding example of fulfilling this mandate. GRObio combines world class science with pioneering approaches to protein engineering to create tomorrow’s therapies or even cures enabling lives free of chronic pain, significantly improved disease management and freedom from life-threatening conditions. It’s exciting that our funding will help the GRObio team expand its platform and advance its assets toward the clinic.”

The proprietary GRO platform, developed in the labs of Dr. George Church, is comprised of the first production organisms with modified genomes that enable the production of proteins with NSAAs – protein building blocks that expand beyond the typical 20 amino acids. The Company’s uniquely scalable and stable production platform delivers protein therapeutics with chemistries and properties previously inaccessible to protein engineering.

GRObio is advancing its first two families of NSAA platform chemistries to build its product pipeline.DuraLogic™ chemistries focus on therapeutic stability and dosing schedule, while ProGly™ chemistriesprovide biologics that reeducate the immune system to treat autoimmune disease, or to eliminate immunogenic side effects of protein-based therapies.

“GRO Biosciences is redefining protein therapeutics by removing the fundamental limitations of producing proteins with NSAAs. Their work opens the doors for a new universe of proteins with therapeutic properties that were previously impossible even to consider. GRObio’s world-class team is only limited by their imaginations,” said Geoffrey W. Smith, JD, Founder and Managing Partner of Digitalis Ventures and GRObio Board Director.


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